Living as a male-to-neutrois person can be difficult because the body needs sex hormones for a number of reasons, including bone health. That means male-to-neutrois people must take estrogen to lose their male characteristics. However, this hormones adds undesirable female characteristics. They also typically take an anti-androgen to block testosterone production. It can be difficult to find the right balance for good health and a desirable appearance.
Some male-to-neutrois people seek castration and penis nullification. However, most often male-to-neutrois individuals simply tuck their penises away to minimize their bulge. While male-to-neutrois individuals who undergo castration become eunuchs, not all eunuchs are neutrois. Many still identify as men, despite the castration.
The term male-to-neutrois only describes gender identity, not sexual identity. Some male to neutrois people are asexual while others are sexually active and enjoy heterosexual, bisexual, and homosexual relationships. Sexually-active male-to-neutrois people most commonly identify as bisexual as the binary gender system does not resonate with them.