Testalgia can be a symptom of gonorrhea or chlamydia, so testing for these sexually transmitted infections should be undertaken if testicular pain is noted to rule these conditions out.
Non-steroidal anti-inflammatory medications and antibiotics are often prescribed to treat testalgia. However, they are not always effective. Surgical measures such as epididymectomies and orchiectomies have also had limited success. Microsurgical testicular denervation has shown better results.